Factor VIIa and Factor IXa Inhibitors as Anticoagulants: A Review
نویسندگان
چکیده
منابع مشابه
Factor IXa Inhibitors as Novel Anticoagulants R1 Howard Factor IXa Inhibitors
Currently available anticoagulants are limited by modest therapeutic benefits, narrow clinical applications, increased bleeding risk, and drug-induced thrombophilia. Because factor IX plays a pivotal role in thrombin generation, it may represent a promising target for drug development. Several methods of attenuating factor IX activity, including monoclonal antibodies, synthetic active site-bloc...
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Coagulation proteases are involved in a highly orchestrated proteolytic cascade which is essential for haemostasis and blood clotting. In particular, the initiator of the coagulation cascade, Factor VIIa, binds to its cofactor, tissue factor, and its substrate, Factor X, via exosite interactions to form a ternary catalytic complex named extrinsic Xase. These exosite interactions have also been ...
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1. Astract 2. Introduction 3. TF and FVIIa 3.1. Purification, cloning and expression of TF 3.2. TF structure and function 3.3. Purification, cloning and expression of FVII 3.4. FVIIa structure and function 3.5. Interaction of FVIIa with TF 3.6. Binding of human FVIIa to sTF, lipidated TF and cell surface TF 3.6.1. FVIIa binding to sTF 3.6.2. FVIIa binding to lipidated TF and to cell surface TF ...
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An association between cancer and thrombosis has been recognized for more than a century. However, the manner by which tumor growth is regulated by coagulation in vivo remains unclear. To assess the role of coagulation on tumor growth, in vivo, we tested coagulation inhibitors specific for either tissue factor (TF)/factor VIIa (fVIIa) complexes or factor Xa (fXa) for antitumor activity. Here, w...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Education and Research
سال: 2017
ISSN: 0019-5464
DOI: 10.5530/ijper.51.1.1